Biofreeze Cool The Pain Spray For over 25 years, Biofreeze has been cooling the nation's pain. Biofreeze cold therapy provides powerful relief from sore muscles, back aches, sore joints and arthritis. The spray format is ideal for people with limited mobility arising from conditions such as arthritis. Specifically developed for those hard to reach areas such as the middle to upper back, neck, and lower extremities. Delivers the same relief when sprayed upside down.